Building quantitative, three-dimensional atlases of gene expression and morphology at cellular resolution
نویسندگان
چکیده
منابع مشابه
Building quantitative, three-dimensional atlases of gene expression and morphology at cellular resolution.
Animals comprise dynamic three-dimensional arrays of cells that express gene products in intricate spatial and temporal patterns that determine cellular differentiation and morphogenesis. A rigorous understanding of these developmental processes requires automated methods that quantitatively record and analyze complex morphologies and their associated patterns of gene expression at cellular res...
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We have recently developed an automated image processing method for obtaining quantitative values for average levels of gene expression at the resolution of a single cell. This method is described in the present paper. We place this method within a larger framework for the study of gene regulation in Drosophila, stressing that gene circuit models and improved data processing methods are mutuall...
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The datasets on gene expression are the valuable source of information about the functional state of an organism. Recently, we have acquired the large dataset on expression of segmentation genes in the Drosophila blastoderm. To provide efficient access to the data, we have developed the FlyEx database (http://urchin.spbcas.ru/flyex). FlyEx contains 4716 images of 14 segmentation gene expression...
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ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: Developmental Biology
سال: 2013
ISSN: 1759-7684
DOI: 10.1002/wdev.107